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Broad-spectrum antifungal agents are commonly used to treat denture stomatitis (Mima et al. Although the drugs can be used topically, however, they are difficult to lion bayer effective because of the large amount of saliva flowing and the protection of biofilm matrix. Therefore, Casemiro et al. As the percentage of Prednisolone Oral Solution (Prednisolone Sodium Phosphate Oral Solution)- Multum zeolite increased from 2.

Moreover, Nikawa et al. The inhibitory effect of C. It was concluded that the soft lining materials had more obvious bacteriostatic efficacy after the addition of silver zeolites.

In a previous study, Nikawa et al. However, the effect of saliva on antibacterial efficacy of silver-zeolite doped soft lining materials had not been systematically addressed in this study (Nikawa et al. Subsequently, Abe et al. It could be concluded that, after 28 days of treatment with water or saliva, there was no significant difference in the bactericidal efficacy of silver-zeolite doped tissue conditioner against C. Currently, intensive studies have been made on the resistance of MOFs to C.

However, there have Hyaluronidase Human Injection (Hylenex)- Multum no reports on the application of MOFs in the treatment of denture stomatitis. The pathogenesis is complex, with local and systemic conditions as well as genetic, immune, and microbial factors that may play a role.

The combination of Chinese and western medicine is often used to treat oral ulcerative disease. But it is difficult to achieve the desired results. It is still difficult to achieve a favorable and satisfied effect on oral mucosal ulcer by current available treatments. In addition, herbs (chamomile extract) were added into the matrix to promote wound healing (Salehi et al.

In addition to the treatment of the above diseases, microporous nanomaterials can also be used for the treatment of oral infections such as jaws osteomyelitis and oral multi-space infection.

Conventional treatment for oral infections is the use of antibiotics (Levi and Eusterman, 2011). However, due to the emergence of drug-resistant strains, the satisfied therapeutic effect is difficult to achieve. Therefore, it is necessary to study novel antibacterial agents for oral infection treatments.

Jaws osteomyelitis is a devastating infection of bone and bone marrow, of which Gram-positive Staphylococcus is one of the most common pathogens (Kavanagh et al. The reason for its excellent antibacterial efficacy was to promote the Prednisolone Oral Solution (Prednisolone Sodium Phosphate Oral Solution)- Multum of ZIF-8 and the release of vancomycin under acidic condition.

Furthermore, it could simultaneously promote the bone regeneration to restore the surrounding bone damage. Similar to jaws osteomyelitis, S. It was found that the antimicrobial diameter of the nanostructured zeolite was larger than that of the micro-sized zeolite, suggesting that nanostructured zeolite had superior antibacterial effect (Figure 6). The difference in the antibacterial effect between different sized zeolites was probably due to the fact that nanoscale silver-exchange zeolite X could release more silver ions.

Due to the short diffusion lengths and higher external surface area of the nanostructured zeolites, compared with the traditional micro-scale zeolites, they have higher ion release efficiency (Izumi and Nakazawa, 1986). Comparison of Ag-nZeo and Ag-mZeo on growth inhibition of MRSA. Notes: (A) Schematic diagram of the bactericidal action of mZeo and nZeo on MRSA and their silver ion release rate.

This article reviewed recent research progress of antibacterial microporous nanomaterials with respect to oral diseases. With the development of drug resistance, it is necessary to find a drug delivery system compatible with a variety of antimicrobial agents and new antimicrobial agents. Novel microporous nanomaterials and their composites offer a valuable opportunity and are compatible with a wide range of antibiotics for oral infectious diseases.

In this paper, three types of microporous frameworks were summarized, including zeolites, metal organic frameworks, covalent organic frameworks, particularly on their potential of antibacterial effects via inherent properties, drug delivery, and modification. Importantly, their application in the treatment of oral infection diseases was detailedly reviewed.

However, it is considered that most of these microporous frameworks and their nanocomposites are uncommercialized and their acquisition procedures are complex, which limits their wide range of clinical applications. Therefore, the faster and more efficient production of these nanomaterials remains to be further investigated.

In addition, more and more studies should be Prednisolone Oral Solution (Prednisolone Sodium Phosphate Oral Solution)- Multum on the biocompatibility improvement and evaluate the therapeutic efficiency against oral diseases in animal studies and clinical trials.

YaW and WX wrote the manuscript. XR and YuW participated and helped with the final revision of the manuscript. LW and BD designed and critically revised the review manuscript. All the authors read and approved the final version of the manuscript prior to submission. This study was supported by the Natural Science Foundation of China Prednisolone Oral Solution (Prednisolone Sodium Phosphate Oral Solution)- Multum 81400487 (LW); China Postdoctoral Science Foundation 2015M581405 and 2017T100213 (LW); General program of Natural Science Foundation of Jilin Province 20200201356JC (LW) and 20200201317JC (CL); and seed grant from Jilin University School of Dentistry (LW).

A review on sustainable synthesis of zeolite from kaolinite resources via hydrothermal process. Eco-friendly method for synthesis of zeolitic imidazolate framework 8 decorated graphene oxide for antibacterial activity enhancement. Toxicity of graphene and graphene oxide nanowalls against bacteria. Zeolite structures loading with an anticancer compound as drug delivery systems. Green synthesis and characterization of novel Mn-MOFs with catalytic and antibacterial potentials.

Iodine-loaded metal organic framework as growth-triggered antimicrobial agent.



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