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Results of parameter estimates. However, neither the main effect of Group in the Good Context (ASD: 1676. The interaction effect in the Good Context was driven by a slightly larger difference in decision time between groups when they made decisions in public (ASD: 1709. Results of decision time (in milliseconds). To examine how the decision-related neural patterns differ in representing information contributing to the value computation and final decisions between ASD participants and HC participants, we performed a within-subject RSA (Fig.

Given our hypotheses, we focused our analysis on the rTPJ. Illustration of within-subject RSAs. For each individual, we first tremors a neural RDM measuring the correlational distances of multivoxel patterns of the decision-relevant neural activities within either left or right TPJ between each pair of valid trials, respectively. Next, we constructed four cognitive RDMs by calculating the Euclidean distances between each pair of valid trials with respect Magnesium Sulfate Injection (Magnesium Sulfate)- FDA the following information: (1) Audience (i.

Notably, we sorted all trials Magnesium Sulfate Injection (Magnesium Sulfate)- FDA to the order of Audience, Moral Context, payoff for the participant, and payoff for associations to guarantee the information contained by both the neural and cognitive RDMs was matched with each other.

Then we performed Magnesium Sulfate Injection (Magnesium Sulfate)- FDA Spearman rank-ordered correlation between the neural and the cognitive RDMs. These significant differences held after ruling out the confounding effect of age. Finally, to further examine the robustness of the above findings, we also applied the above analyses using all 256 trials, which did not affect the results (Fig.

A, B, Within-subject RSA results using the parcellation-based ROI (A) social learning the coordinate-based ROI (B) of TPJ.

For each participant, we only adopted valid trials (see Materials and Methods for details) in these analyses. For each participant, we adopted all 256 trials in these analyses. One possibility could be that the neural audience effect of rTPJ was modulated by large individual differences in the behavioral Magnesium Sulfate Injection (Magnesium Sulfate)- FDA effect across individuals, which blurred the main effect.

To test this possibility, we extracted the mean activity (contrast value) of the rTPJ from each condition, and then computed a neural index of audience effect for each individual (i.

We also defined a behavioral index of audience effect on the proportion of moral choice, which was calculated with the Magnesium Sulfate Injection (Magnesium Sulfate)- FDA equation. Furthermore, the between-group comparison did not reveal a significant result in the audience effect in rTPJ (i.

Besides, no significant difference in the neural activity was observed in the rTPJ between the Japanese and Bad Contexts in the HC group or between two groups (i.

For the completeness of the analyses, we also applied the same analyses to lTPJ, yielding similar results (Figs. Univariate results of TPJ in healthy control subjects. A, Bar plot of TPJ signals. B, Relationship between neural audience effect in TPJ and behavioral audience effect across individuals.

Each line represents the linear fit. A, B, Univariate results of TPJ in the HC and ASD groups using the parcellation-based mask (A) and the coordinate-based mask (B).

When facing moral dilemmas such as earning ill gotten money by supporting a bad cause or donating to a charity at a personal cost, how do autistic individuals choose. What neurocomputational mechanisms underlie such behavioral changes. Our behavioral results reveal that the moral behavior of ASD individuals differs from healthy control subjects in two aspects. First, ASD individuals, unlike healthy control subjects, blurred the distinction between private and public conditions while making moral decisions.

This finding not only coheres with the ToM deficit hypothesis of ASD individuals (Baron-Cohen et al. Moreover, it extends the lack of attention to social reputation in autism to include an immoral context where individuals are confronted with a moral conflict between personal profits and a cost brought by benefiting an immoral cause.

Second, a robust behavioral difference between ASD individuals and healthy control subjects was found specifically in one moral context. ASD individuals generally refused Magnesium Sulfate Injection (Magnesium Sulfate)- FDA offers in the Bad Context that could have earned extra money for themselves but resulted in an immoral consequence.

No similar between-group difference was observed in the Good Context. Note that decision difficulty cannot explain these behavioral effects because no decision time difference was observed between the two groups. Our computational modeling approach provides crucial insights to understand further this difference in ASD individuals, which is specific to moral behaviors serving a bad cause.

In parallel to the choice findings, ASD individuals drastically lowered their decision weights on payoffs that Magnesium Sulfate Injection (Magnesium Sulfate)- FDA be earned both for themselves and the morally bad cause, whereas they valued the personal losses and the benefits of the charity similarly to healthy control subjects.

These findings strongly indicate an atypical valuation of morally tainted personal profits and moral costs brought by benefiting a bad cause in autistic individuals. This probably led to their extremely high rejection rate for immoral offers. Our results fit the literature on moral judgment, vagina teen has shown that ASD individuals exhibit an excessive valuation of negative consequences when judging the moral appropriateness or permissibility of actions.

For example, Moran et al. In agreement with these findings, our results suggest that autistic individuals may apply a rule of refusing to serve an immoral cause because they evaluate the negative consequences of their actions more pfizer novartis. This might result in insensitivity in ASD individuals who have difficulty in adjusting their behaviors regarding their personal interests that might be associated with immoral consequences.



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